Complete sequences of two plasmids in a blaNDM-1-positive Klebsiella oxytoca isolate from Taiwan.

نویسندگان

  • Tzu-Wen Huang
  • Jann-Tay Wang
  • Tsai-Ling Lauderdale
  • Tsai-Lien Liao
  • Jui-Fen Lai
  • Mei-Chen Tan
  • Ann-Chi Lin
  • Ying-Tsong Chen
  • Shih-Feng Tsai
  • Shan-Chwen Chang
چکیده

Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (bla(CTX-M-3) and blaSHV-12) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 57 8  شماره 

صفحات  -

تاریخ انتشار 2013